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KMID : 0361020110540080550
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Korean Journal of Otolaryngology - Head and Neck Surgery
2011 Volume.54 No. 8 p.550 ~ p.556
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Follicular Variant of Papillary Thyroid Carcinoma: Clinical Manifestation and Prognosis
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Jeong Mun-Sang
Cho Pyung-San
Park Hoon
Choi Ik-Jun
Lee Byeong-Cheol
Lee Guk-Haeng
Lee Yong Sik
Lee Myung-Chul
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Abstract
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Background and Objectives : Despite relatively high incidences of follicular variant of papillary thyroid carcinoma (FV-PTC), there is a continuous debate regarding the clinical behavior, treatment outcome, prognostic variables and survival of this disease. We performed this study for the purpose of getting further understanding and more supporting ideas for the treatment of FV-PTC.
Subjects and Method : A clinicopathologic analysis of 116 patients who underwent a thyroidectomy with a final diagnosis of FV-PTC divided the patients into three groups: the FV-PTC only group (group A, n=78), the FV-PTC group who developed classical papillary thyroid carcinoma (C-PTC) (group B, n=38) and the C-PTC only (group C, n=320, 2003, Korea Cancer Center Hospital). The three groups were compared with respect to the following various clinicopathological characteristics: age at diagnosis, tumor size, stage of tumor, capsular invasion, age, metastasis, extent, size score, multifocality of tumor, LN metastasis, treatment, and recurrence.
Results: The mean tumor sizes, disease stage, and type of initial surgery were similar in three groups. However, the prevalence of nodal disease and capsular invasion were significantly higher in the groups B and C compared to the patients of group A. The 8-year disease-free survival rate was 93.7% in the patients with FV-PTC only, 90.4% in the patients with C-PTC only and 88.2% in the patients with FV-PTC group, who developed C-PTC (p>0.05).
Conclusion: The clinical behavior and prognosis of PTC and FV-PTC groups did not differ significantly. In treating FV-PTC, we find that it is desirable to choose a similar strategy as that used to treat C-PTC.
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KEYWORD
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Papillary thyroid carcinoma, Follicular variant of papillary thyroid carcinoma, Prognosis, Recurrence
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